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REACT-Led Clinical Trials in Medical Rehabilitation

The following clinical trials are led by REACT investigators. To learn more contact us.

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  1. This randomized, placebo-controlled trial - a collaboration between two major academic medical centers (University of Kentucky and University of Alabama at Birmingham) - is designed to determine if the addition of a medication (Metformin) will improve the effectiveness of strength training in older adults. The overall goal is to establish a low cost, personalized approach to prevent frailty in older adults.

    Funding: NIH R01AG046920

    Principal Investigators: Charlotte Peterson, PhD, Phil Kern, MD, Marcas Bamman, PhD

    Institutions: Univ. Kentucky and UAB Identifier: NCT02308228

  2. Are you a breast cancer survivor having difficulty walking? Do you have any lower-body pain that is restricting your mobility? If so, you may be interested in taking part in an exercise training intervention. UAB researchers are currently looking for overweight women with a history of breast cancer to participate in a novel exercise training study. Volunteers will be asked to attend two assessment sessions, before and after 8 weeks of supervised exercise training, to collect information concerning your health status. Volunteers must be 18-70 years of age with a body mass index between 30–45 kg/m2. Further eligibility screening will be conducted by telephone for those interested. Volunteers must reside in or near Jefferson County, Alabama. The goal of the study is to evaluate a novel exercise training strategy designed to mimic exercise at higher altitude to support improved health and mobility among breast cancer survivors.

    Funding: NIH R01HD085186

    Contact: Dr. Stephen J. Carter (205.975.0269 or or the UAB Exercise and Cancer Research Team (205.934.5466 or Identifier: NCT03029182

  3. The study uses a theory-driven eHealth platform and innovative PA program referred to as movement-to-music (M2M) to deliver a customized, home-based PA intervention for adults with physical disability. Participants will be recruited through a large physical medicine and rehabilitation network of clinics specializing in treating patients with physical disability. Clinicians and their patients will be cluster randomized to one of three groups: a) M2M; b) M2M plus social networking (M2Mplus); and c) attention control (AC). Participants will be followed for 48 weeks to obtain objective measures on physical activity, fitness and self-reported measures on health at four time points. Participant physicians will receive information on their patients’ progress (i.e., adherence and outcomes) across the 48-week study period. The study will compare the effectiveness of M2M and M2Mplus in increasing physical activity and adherence compared to the AC group, estimate the improvements in health of M2M and M2Mplus compared to the AC group, and examine the mediators and moderators of the hypothesized treatment effect to understand for whom and how the intervention is effective.

    Funding: NIH R01HD085186

    Principal Investigator: James Rimmer, PhD; Co-Investigator: Amie McLain, MD Identifier: NCT03024320

  4. The objective of this pilot study is to investigate the effects of a 6-week structured exercise program on memory function and associated brain network connectivity in persons with epilepsy (PWE). Despite the benefits of physical exercise on cardiovascular and psychological health, and its potential to improve seizure control and overall quality of life in PWE, patients are often cautioned against vigorous exercise. Only a few studies of supervised exercise in PWE have been conducted, and these have mainly investigated the influence of exercise on seizure frequency. There is a paucity of studies investigating the effects of physical exercise on cognition in PWE. Memory impairment is a frequently reported cognitive problem by PWE and is a common factor contributing to poor quality of life in PWE. Successful completion of this project will provide preliminary data to inform the development of future research applying exercise to help improve cognitive abilities in PWE. Support for this project is provided by the UAB Faculty Development Grant Program, the UAB Epilepsy Center, the Civitan International Research Center, and the UAB Center for Exercise Medicine Research Acceleration Program.

    Research Team: Jane B. Allendorfer, PhD (PI), Marcas M. Bamman, PhD, Lawrence W. VerHoef, MD, Jerzy P. Szaflarski, MD, PhD, Roy Martin, PhD

    Contact: Dr. Jane Allendorfer, 205-934-3866 or

  5. The purpose of this project is to conduct a randomized, controlled trial (RCT) to determine if choice of antihypertensive medication influences changes in functional status and other cardiovascular risk factors among older persons with hypertension. Sedentary men and women ≥ 60 years of age with functional limitations and hypertension will be recruited from two sites to participate in a longitudinal intervention trial. Participants will be randomly assigned to one of three first-line antihypertensive agents and participate in a structured aerobic exercise intervention. This study is expected to differentiate beneficial effects of three FDA-approved antihypertensive medications on established and emerging cardiovascular risk factors in a clinically-relevant population.

    Funding: NIH R01AG056769

    PIs: Thomas Buford, PhD, UAB; Wendy Kohrt, PhD, Univ. of Colorado identifier: NCT03295734

    Contact: Call 205-930-8597

  6. The purpose of this study is to evaluate the impact of a 16-week resistance and interval intensity training program for older adults with HIV on mitochondrial function and frailty risk. Participants will be HIV+ men and women between the ages of 55 and 85.

    Study Visits: Participants will complete one screening visit at the beginning of the study and one follow-up visit at week 16. There will be three visits each week for exercise training at the UAB Center for Exercise Medicine over the 16-week training period. Support for this project is provided by the UAB Center for Exercise Medicine and the CCTS.

    Research Team: Mandy Willig, PhD, RD, Turner Overton, MD, Marcas Bamman, PhD, Victor Darley-Usmar, PhD

    Contact: Dr. Mandy Willig at 205-975-5464 or

  7. The purpose of the CALM study is to evaluate the effects of 12 weeks of exercise alone or exercise plus counseling on weight loss, fitness, cholesterol, triglyceride, blood sugar levels, behavior and mental health in overweight females between the age of 25 and 44.

    CALM Study Research Team: Jane Roy, PhD (PI), Sean Hall, PhD, Eric Plaisance, PhD, Larrell Wilkinson, PhD, Larry Tyson, PhD

    Contact: Dakota at 205-996-1656 or, or Dr. Jane Roy at 205-934-1757.

  8. The purpose of the study is to compare the effects of a walking program on long term exercise adherence and on changes in health related outcomes after breast cancer diagnosis. Volunteers will be asked to attend four fitness assessments within a year and may be asked to attend twelve supervised exercise sessions and six group sessions within a 3-month period. You will also have your metabolism measured through two techniques.

    No medications or treatments other than exercise will be given as part of the study. All individual exercise sessions will be supervised by trained exercise specialists.

    We hope the study results help us to better understand breast cancer and benefit patients with this disease in the future. Studies such as these would not be possible without volunteers.

    Please contact the Exercise and Cancer Research Team at (205) 975-1247 if you would like to learn more about the study.

    Funding: NIH U01CA136859

    Study Team: PI: Laura Rogers, MD MPH (UAB), Co-Investigators: Philip Anton, PhD (SIUC), Edward McAuley, PhD (Illinois), Kerry Courneya, PhD (University of Alberta), Patricia Hopkins-Price, PhD (SIUSOM), Robert Mocharnuk, MD (SIUSOM), Steve Verhulst, PhD (SIUSOM), Sandra Vicari, PhD (SIUSOM), Robert Oster, PhD (UAB) identifier: NCT00929617

  9. The HEART Matters Program is a way to promote healthy behaviors among Black men. Through funding from a MHRC grant, the program offers health coaching from Dr. Larrell Wilkinson to Black men ages 24-64 who are overweight or obese and have a desire to become healthier. The program aims to promote a more active lifestyle, a healthier diet, stress management and resting among Black men. The grant also allows for the training of men to become leaders in their peer groups to help other men become healthier. The health coaching approach used embraces a philosophy of placing the individual first and weight management second. The hope of the HEART Matters Program is to unite African American men in solidarity to help one another improve their health, their quality of life, and take the lead on health issues in their families.

    Contact: Dr. Larrell Wilkinson

    HEART Matters Team: PIs: Larrell Wilkinson, PhD, Eric Plaisance, PhD

  10. This study, funded by the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR), compares walking outcomes associated with two different training programs in people who have experienced a stroke. The two training programs are each a 10-week intensive treadmill training program with 5 different exercise regimens. Both forms of training make use of a robotic device called the KAMX. The KAMX is a robotic device that allows full freedom of motion for the body and pelvis during walking and balance tasks, and also helps to control posture to enhance balance and stability. Dr. David A. Brown, Professor of Rehabilitation Science and his team are currently recruiting individuals who have experienced a stroke and who have difficulty with walking and balance.

    Contact: The UAB LocoLab Identifier: NCT02787694

  11. The PHITE program will explore the link between physical training and epigenetics and will use that understanding to (1) identify training methodologies that modify epigenetics responses; (2) characterize epigenetic regulation of physiological processes, pathways, and mechanisms associated with moderate and high-intensity physical training: and (3) produce real-time biomarkers of cardiorespiratory and neuromuscular performance that predict physical training outcomes.

    Funding: Department of Defense MURI

    Principal Investigators: Timothy J. Broderick, MD (Wright State), Marcas M. Bamman, PhD (UAB)

    Institutions: Wright State University Boonshoft School of Medicine, Wright State University, The Salk Institute, UAB

  12. The purpose of this randomized, controlled interventional study is to determine the effects of a high intensity exercise training program on objective sleep measures, daytime sleepiness, mobility, and brain health/functional connectivity in patients with Parkinson's disease.

    Contact the study team: Dr. Amara (principal investigator) 205-934-0683; Dr. Wood 205-996-7938 Identifier: NCT02593955

  13. This randomized clinical trial is designed to test the central hypothesis that progressive resistance training plus adjunctive funcational mobility training after THA/TKA will more effectively restore muscle mass and mobility function to healthy standards than usual care and, because individuals with abnormally high muscle TWEAK signaling are predicted to suffer failed muscle recovery and persistent dismobility under usual care, the impact of the intervention will be greatest among these patients.

    Funding: NIH R01HD084124

    Principal Investigators: Marcas Bamman, PhD; Louis Bridges, MD, PhD

    Institutions: UAB and UAMS Identifier: NCT02628795