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NCATS announces awards for tissue chip for disease modeling and efficacy testing

In September 2017, NIH funded 13 institutions with initial two-year awards to further develop tissue chip models of human disease that mimic the pathology in major human organs and tissues. The goals are to: 1) support studies to develop in vitro disease models using primary tissue or induced pluripotent stem cell (iPSC)-derived patient cell sources on tissue/organ-on-chip platforms; 2) determine disease relevance of these models by preliminary testing of key experimental features; and 3) test the effectiveness of candidate drugs.

Learn more about these awarded projects:

  • Kidney Microphysiological Analysis Platforms to Optimize Function and Model Disease
  • Development of a Microphysiological Organ-on-Chip System to Model Amyotrophic Lateral Sclerosis and Parkinson’s Disease
  • Multi-Tissue Platform for Modeling Systemic Pathologies
  • Systemic Inflammation in Microphysiological Models of Muscle and Vascular Disease
  • Lung-on-a-Chip Disease Models for Efficacy Testing
  • Multi-Scale Modeling of Inherited Pediatric Cardiomyopathies
  • Polycystic Ovary Syndrome (PCOS) and Androgen-Related Disease Modeling and Drug Testing in Multi-Organ Integrated Microfluidic Reproductive Platform
  • A 3-D In Vitro Disease Model of Atrial Conduction
  • Microphysiological Systems to Model Vascular Malformations
  • Tissue Chip Modeling of Synovial Joint Pathologies: Effects of Inflammation and Adipose-Mediated Diabetic Complications
  • Engineered Salivary Gland Tissue Chips
  • A Microphysiological System for Kidney Disease Modeling and Drug Efficacy Testing
  • Drug Development for Tuberous Sclerosis Complex and Other Pediatric Epileptogenic Diseases Using Neurovascular and Cardiac Microphysiological Models

Posted: Sept. 12, 2017