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Oct. 29, 2019

NCMRR Rehabilitation Research News: November 29, 2019

This bi-monthly newsletter is published by the National Center for Medical Rehabilitation Research (NCMRR) of the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

Sept. 26, 2019

Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double‐blind, placebo‐controlled, multicenter trial: The MASTERS trial

In this study, investigators sought to determine whether the hypertrophic response to progressive RT (PRT) would be improved by the addition of metformin compared to placebo.

June 26, 2019

Regulatory Perspective: Digital Health Technology Tools

At FDA, there is a focus on evaluating and considering valuable novel approaches and tools that can support regulatory decision-making. The dramatic growth and incorporation of digital technologies into daily life has afforded new opportunities to use these tools to understand patients’ functioning and how it is affected by different diseases and treatments.

March 21, 2019

Scientists rise up against statistical significance

In this comment in the March 20, 2019 issue of the journal, NATURE, Valentin Amrhein, Sander Greenland, Blake McShane and more than 800 signatories call for an end to hyped claims and the dismissal of possibly crucial effects.

July 11, 2018

A Resource Supporting High Quality and Cost Effective Clinical Trials: The NCATS Trial Innovation Network

This important resource helps investigators conduct faster and more cost-effective high-quality multi-site clinical trials.

June 11, 2018

The scandal of poor medical research

Douglas Altman, a professor of statistics in medicine at the University of Oxford , recently died at the age of 69. He waged a long-running campaign to improve the use of statistics in medical research.

June 5, 2018

Assembling a comprehensive map of the molecular changes that occur in response to movement

NIH Common Fund's Molecular Transducers of Physical Activity in Humans program aims to catalogue the biological molecules affected by exercise in people, to assemble a comprehensive map of the molecular changes that occur in response to movement and, when possible, relate these changes to the benefits of physical activity. It's getting a lot of attention.

Sept. 29, 2017

Stroke patients benefit from at-home therapy video game trial based at UAB

REACT Pilot Award-winner Gittendra Uswatte PhD, professor in the College of Arts and Sciences’ Department of Psychology and associate director of the CI Therapy Research Group and Taub Therapy Clinic, has developed a video game that allows stroke patients to practice Constraint-Induced Movement therapy.

Sept. 23, 2017

The Internet and social media may offer valuable support and information for people with TBI

In a recent NIDILRR-funded study, researchers looked at Internet and social media usage habits among adults with TBI. Researchers wanted to find out whether people with TBI use the Internet more or less than people without disabilities, and which subgroups of people with TBI were most and least likely to use the Internet.

Sept. 7, 2017

Neurotech: Virtual clinical trials: What investigators are learning about the challenge and opportunities

Virtual visits using remote technologies and devices can help improve access, enrollment, diversity, and even the quality of data gathered in clinical trials, researchers told Neurology Today. But issues of feasibility, reliability, and data correlation remain, they said.

Aug. 24, 2017

Effectiveness of a timing and coordination group exercise program to improve mobility in community-dwelling older adults

This original research study examined a group exercise program that incorporated timing and coordination exercises compared to a usual care exercise program for improving mobility in community-dwelling older adults.

Aug. 11, 2017

Master protocols to study multiple therapies, multiple diseases, or both

Authors in this review article propose that researchers should consider the use of master protocols to evaluate more than one or two treatments in more than one patient type or disease within the same overall trial structure.

Aug. 10, 2017

Woman can move again after a breakthrough stroke treatment

The first person to receive deep brain stimulation for stroke recovery is performing far better than her doctors anticipated.

June 25, 2017

Smartphones open a new world for medical researchers

When smartphones first began collecting health data such as users’ heart rates and number of steps walked, doctors were dubious about the medical value of information gathered by a phone.

June 1, 2017

TBI-induced nociceptive sensitization is regulated by histone acetylation

In this original research study, the authors characterized TBI-induced bleeding and blood-brain barrier breakdown after lateral fluid percussion injury.

March 19, 2017

Biopsychosocial rehab approach may ease intense CNS pain

Central sensitization improved with treatment in an interdisciplinary chronic pain rehabilitation program, according to a preliminary analysis presented at the American Academy of Pain Medicine.

March 1, 2017

Physical exercise restores the generation of newborn neurons in an animal model of chronic epilepsy

In this original research article, the authors show that there is a reduction in the generation of newborn granule cells in the dentate gyrus of adult rats subjected to a chronic model of epilepsy during the postnatal period of brain development.

Feb. 21, 2017

Monitoring gait in multiple sclerosis with novel wearable motion sensors

In this original research study, the investigators applied a novel wireless, skin-mounted, and conformal inertial sensor (BioStampRC, MC10 Inc.) to examine gait characteristics of PwMS under controlled conditions and to determine the accuracy and precision of BioStampRC in measuring gait kinematics by comparing to contemporary research-grade measurement devices.

Jan. 27, 2017

UAB study led by REACT Co-Director Gary Cutter named by NEJM as one of the top neurology stories of 2016

A study on the efficacy of surgery to remove the thymus in myasthenia gravis patients, led by researchers at the University of Alabama at Birmingham, has been named one of the top neurology stories of 2016 by the New England Journal of Medicine Journal Watch.

Jan. 5, 2017

Vision symptoms following concussion can limit a child’s ability to return to the classroom

A comprehensive vision assessment should be part of return-to-learn protocols to help determine when children are ready to return to the classroom following concussions — particularly in children reporting academic difficulty.

Dec. 1, 2016

Stem cell therapy gives paralyzed man second chance at independence

Four days after undergoing major surgery, 21-year-old Kris Boesen picked up a smartphone and sent a text. It was the first message that he had sent in months. What was truly remarkable was that Kris once almost completely paralyzed was holding a phone at all.

Oct. 16, 2016

Robot exoskeletons march in to link mind and body

Originally designed to give soldiers superhuman strength, exoskeletons are enabling heroic efforts to help patients re-learn to walk.

Aug. 23, 2016

Emerging relationships between exercise, sensory nerves, and neuropathic pain

In this original research study, the authors encourage clinicians and researchers to continue to examine and highlight the myriad of benefits which exercise provides. and that future research should continue to examine the use of exercise in a clinical setting, looking to answer what changes occur in different neural compartments that underlie reductions in pain.

Aug. 22, 2016

Stem cell therapy heals injured mouse brain

Scientists and clinicians have long dreamed of helping the injured brain repair itself by creating new neurons, and an innovative NIH-funded study published today in Nature Medicine may bring this goal much closer to reality. A team of researchers has developed a therapeutic technique that dramatically increases the production of nerve cells in mice with stroke-induced brain damage.

July 18, 2016

Cardiac rehab saves lives. So why don't more heart patients sign up?

When Mario Oikonomides was 38 years old he had a massive heart attack. About a month later, after he'd recuperated from the emergency, his doctors sent him to a cardiac rehabilitation program, where he learned about the role physical activity can play in reducing cardiac risk.

June 15, 2016

In-hospital mobility program proves successful for patients’ posthospital function

University of Alabama at Birmingham investigators found that patients who participated in a mobility program were less likely to experience a decline in mobility when compared to the usual care provided during hospitalization.

May 21, 2016

For people with disabilities, new technology can be life changing

For most of us, eye tracking technology sounds interesting. Eye tracking allows users to move a cursor around a computer or mobile device simply by moving your eyes and head. But it can be life changing.

April 11, 2016

A Fitbit saved his life? Well, maybe

You may already know that electronic fitness trackers can let you keep records on your smartphone of how many steps you've walked, how much you've slept, maybe your heart rate, or even where you've been. But what can the gadget tell your doctor? A few things that are pretty useful, it turns out.

March 21, 2016

The benefits of intensive cardiac rehabilitation over ordinary cardiac rehabilitation

Despite considerable progress in prevention and treatment, heart disease continues to be the leading cause of death in the United States. When patients suffer from a heart attack or other cardiac event, it's critical that they get appropriate care and adopt lifestyle changes to prevent future damage.

Feb. 22, 2016

We all know exercise makes you live longer. But this will actually get you off the couch.

When someone dies in the intensive care unit, the first thing the nurse does is turn off the EKG monitor. That’s because the heart can go on depolarizing — writing its electrical signature on the screen, if not actually pumping blood — for many minutes after everything else stops. Because the heart is the soldier who can’t bear to surrender until long after the battle is lost.

Feb. 17, 2016

Which type of exercise is best for the brain?

Some forms of exercise may be much more effective than others at bulking up the brain, according to a remarkable new study in rats. For the first time, scientists compared head-to-head the neurological impacts of different types of exercise: running, weight training and high-intensity interval training.

Dec. 18, 2015

Ten-year-old concussed patient participates in research to identify biomarkers in mild traumatic brain injuries

Lewis Rand, an active 10-year-old, suffered a mild traumatic brain injury Oct. 20 during soccer practice when he fell, hitting his head on a metal post. Lewis did not think anything of the incident and continued practicing. But as symptoms developed over the following days, Lewis was ultimately referred to Children’s of Alabama.

Nov. 23, 2015

Trial combining exercise and a drug may help seniors muscle up

A drug that might help older adults regrow muscle is under investigation at the University of Alabama at Birmingham. UAB is recruiting healthy adults age 65 and older for a study combining strength training exercise with the anti-diabetes drug metformin.

May 18, 2015

First patient-led research registry for arthritis patients launched

CreakyJoints , an online, nonprofit, patient support community with more than 80,000 members, has launched Arthritis Power, the first patient-led, patient-generated, patient-centered research registry for arthritis, bone, and inflammatory skin conditions.

May 11, 2015

Muscle inflammation susceptibility predicts THA recovery

Muscle inflammation susceptibility status seems to be able to predict recovery after total hip arthroplasty, according to research published in the April 15 issue of the American Journal of Physiology, Endocrinology and Metabolism.

Nov. 10, 2014

DOD grant to fund UAB rehabilitation therapy for wounded warriors

The University of Alabama at Birmingham is launching a research project that will provide therapy to wounded veterans and active-duty personnel at no cost through a $2.7 million grant from the U.S. Department of Defense.

Jan. 24, 2014

High-intensity strength training shows benefit for Parkinson's patients

Researchers at the University of Alabama at Birmingham say that high-intensity strength training produced significant improvements in quality of life, mood and motor function in older patients with Parkinson’s disease. The findings were published Jan. 9 online in the Journal of Applied Physiology.