Alliance for Regenerative Rehabilitation Research and Training (AR3T) 6th Annual Symposium + REACT Clinical Trials Workshop

November 1–3, 2017

AR3T

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Wyndham Grand Downtown Pittsburgh
Pittsburgh, PA

6th Annual International Symposium on Regenerative Rehabilitation + Clinical Study Design for Regenerative Rehabilitation Researchers: A REACT Center Workshop

Pittsburgh, PA

Nov 1-3, 2017

The Symposium on Regenerative Rehabilitation is the largest medical and scientific conference specific to Regenerative Rehabilitation in the world, bringing together two disparate disciplines, regenerative medicine and rehabilitative research, into one synergistic field of science. Innovative ideas, concepts and technologies are shared, deliberated and debated at this premier event.

World-renowned researchers and clinicians present on scientifically rigorous and cutting-edge research and clinical management, focusing on new and innovative approaches that combine discoveries in tissue engineering, medical devices and cellular therapies with rehabilitative protocols. This forum presents a unique opportunity for attendees to explore differences in perspectives, contributions, and theories, as well as to discuss benefits and challenges of approaches, leading to the advancement of research and clinical outcomes.

Network with the international, multidisciplinary group of attendees through formal and informal opportunities throughout the Symposium, sharing ideas and forming collaborative relationships. Convene over meals, during refreshment breaks, at the poster session, and during the evening receptions for discussion and cross-discipline pollination to advance innovation in research and practice. Students and trainees may also network with their peers at the Future Leaders of Regenerative Rehabilitation Social.

Clinical Study Design for Regenerative Rehabilitation Researchers: A REACT Center Workshop
Friday, November 3, 12:30–2:30pm EST
at the Wyndham Grand Downtown Pittsburgh

The goal of this workshop is to address challenges and current opportunities specific to clinical trials in medical rehabilitation, including: trial design, issues in recruitment and retention, funding opportunities, and mobile technology integration into rehabilitation trials. We will also introduce investigators to additional clinical trial resources, including the REACT Center and the Medical Rehabilitation Research Resource (MR3) Network Coordinating Center.

Outline

Following an introductory lecture, workshop participants will divide into breakout sessions based on their experience level as investigators:

  • Junior
  • Mid-Career/Interim
  • Senior

Special travel awards are available for Symposium attendees who also register for this workshop. Please see Travel Awards for more information.

Intended Audience

Researchers at all levels of training/expertise who are interested in clinical trials are welcome to attend.

Presenters

The sessions will be led by Dr. Marcas Bamman, Director of the National Rehabilitation Research Resource to Enhance Clinical Trials (REACT), along with Dr. Gary Cutter, Co-Director, REACT and professor of biostatistics in the Section on Research Methods and Clinical Trials in the Department of Biostatistics at the UAB School of Public Health; and Dr. Robert Motl, REACT Mobile Technology Lab Director, Associate Director for Rehabilitation Research at the UAB Center for Exercise Medicine, and professor in the UAB Department of Physical Therapy.

Biosketch

Marcas Bamman, PhD, FACSM:
Professor, Department of Cell, Developmental, and Integrative Biology
Director, UAB Center for Exercise Medicine
Director, P2CHD086851 National Rehabilitation Research Resource to Enhance Clinical Trials (REACT)
Director, T32HD071866 Interdisciplinary Training in Pathobiology and Rehabilitation Medicine

Exercise profoundly impacts the integrity and function of every major organ system, and is therefore considered the only pluripotent form of medicine available. To maximize impact on disease progression, prevention (i.e. risk factor mitigation), and rehabilitation, the state-of-the-art in research is a focus on dose-response trials to provide the evidence base that yields optimal prescriptions in a disease-specific and population-specific manner. The UAB Center for Exercise Medicine is among the nation’s leaders in this effort, with significant emphasis on exercise as an effective form of regenerative medicine to restore the function of cells, tissues, and whole organ systems that have suffered the consequences of aging, disease, damage, or congenital defects. The Center is currently leading clinical and translational research in aging, Parkinson’s disease, multiple sclerosis, ALS, spinal cord injury, epilepsy, head and neck cancer, heart failure, osteoarthritis, HIV frailty, and post-surgical rehabilitation (i.e. following total joint replacement and organ transplantation).

Over the years Dr. Bamman has directed several exercise clinical trials including randomized dose-response trials focused on aging (e.g., NIH 5R01AG017896, NCT02442479), and he is currently the overall Principal Investigator (PI) or site PI of five, multi-site randomized exercise trials focused on: (i) molecular transducers of exercise-induced health benefits (NIH Common Fund MoTrPAC trial, U01AR071133); total joint arthroplasty rehabilitation (NIH R01HD084124, NCT02628795); (ii) aging with mobility impairment (NIH R01AG046920, NCT02308228); (iii) Parkinson’s disease (Curry Foundation); and (iv) epigenetic determinants of exercise responsiveness (Department of Defense MURI trial). All of his human studies are biologically driven – centered on cellular/ molecular analyses of biospecimens and primary stem cells coupled with thorough in vivo phenotyping in healthy (19 to 83 y/o) and diseased – to better understand mechanisms of exercise-induced improvements in neuromuscular function and muscle mass/quality in the face of atrophy and dysfunction in acute (e.g., surgery, trauma, disuse, burn) or chronic (e.g., Parkinson’s, arthritis, cancer, spinal cord injury) conditions. Dr. Bamman has served on >35 federal review panels and NIH study sections, including a 4-year term serving the NIH/CSR Skeletal Muscle and Exercise Physiology (SMEP) study section.

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