Marcas Bamman, PhD

Administration and Executive Committee

  • P2C Principal Investigator
  • Administrative Component Director
  • Consultation Component Associate Director
  • Education and Training Coinvestigator
  • Mobile Technology Laboratory Coinvestigator

Dr. Bamman is a professor in the Departments of Cell, Developmental, and Integrative Biology; Medicine; and Neurology in the UAB School of Medicine and Director of the UAB Center for Exercise Medicine, which is 1 of 24 university-wide interdisciplinary research centers. Dr. Bamman is internationally recognized for his scientific contributions to the biology of human skeletal muscle and medical rehabilitation. He is PD/PI of the NIH National Rehabilitation Research Resource to Enhance Clinical Trials (REACT, P2CHD086851); PD/PI of the Coordinating Center for the NIH National Medical Rehabilitation Research Resource Network (MR3 Network); and founding Director of the 74-site, CTSA Consortium-affiliated the National Exercise Clinical Trials Network (NExTNet) – all of which are designed to foster and increase the scientific rigor and impact of clinical trials. Additionally, Dr. Bamman is PD/PI of the pre- and post-doctoral training program, Interdisciplinary Training in Pathobiology and Rehabilitation Medicine (NCMRR 5T32 HD071866).

Dr. Bamman has directed several exercise rehabilitation clinical trials including randomized dose-response trials (e.g., NCT02442479), and he is currently the overall PI or site PI of five, multi-site randomized exercise trials focused on: (i) molecular transducers of exercise-induced health benefits (NIH Common Fund MoTrPAC trial, U01AR071133); (ii) total joint arthroplasty rehabilitation (NIH R01HD084124, NCT02628795); (iii) aging with mobility impairment (NIH R01AG046920, NCT02308228); (iv) Parkinson’s disease (Curry Foundation); and (v) epigenetic determinants of exercise responsiveness (DoD ONR MURI N00014-16-1-3159, NCT03380923). All of his human studies are biologically driven with the goal of better understanding mechanisms underpinning exercise-induced improvements in neuromuscular function and muscle mass/quality in acute (e.g., surgery, trauma, disuse, burn) or chronic (e.g., Parkinson’s, arthritis, cancer, spinal cord injury) conditions.

As the overall PD/PI of REACT and Administrative Component Director, Dr. Bamman oversees the operation of each component charged with meeting the needs of medical rehabilitation researchers seeking to conduct clinical trials. He is ultimately responsible for ensuring that REACT provides open access resources and services of the highest quality in (i) supporting clinical trials training and education, (ii) planning, implementing, and managing, and (iii) maximizing trial efficiency and potential impact by facilitating the use of REACT core facilities, databases, and/or existing multicenter networks.

Dr. Bamman’s Publications